What is the recommended antidote for Coumadin overdose?

The recommended antidote for Coumadin (warfarin) overdose is Vitamin K. Coumadin works as an anticoagulant by inhibiting the synthesis of vitamin K-dependent clotting factors, which include factors II, VII, IX, and X. When a patient has an overdose of Coumadin, they are at increased risk for bleeding due to the depletion of these clotting factors.

Administering Vitamin K helps to reverse the effects of Coumadin by providing the body with the necessary vitamin to produce new clotting factors. This process is essential in restoring the normal clotting function, thus reducing the bleeding risk associated with overdose.

In contrast, while activated charcoal may be used to reduce absorption in the case shortly after ingestion, it does not directly counteract the effects of warfarin once it is already in the bloodstream. Protamine sulfate is an antidote specifically for heparin and does not have an effect on warfarin. Calcium supplements do not have a role in reversing Coumadin's effects and would not serve as an antidote in this situation. Therefore, Vitamin K is the appropriate and effective treatment for managing Coumadin overdose.